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KMID : 1143420180110311006
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Public Health Weekly Report
2018 Volume.11 No. 31 p.1006 ~ p.1011
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Advances in the development of biomarkers to evaluate the protective efficacy of tuberculosis vaccine
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Lee Young-Ran
Jeong Hye-Sook
Shin Eun-Kyung
Yun Jin-Seung
Yoo Jung-Sik
Chung Gyung-Tae
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Abstract
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Background: One of the most effective interventions for tuberculosis is immunization with Bacille-Calmette-Guerin (BCG)
vaccine, which is the only licensed vaccine against tuberculosis. However, its protective efficacy against M. tuberculosis
infection in adults is limited. Thus, the development of a new vaccine is urgently needed. Currently, there are no validated
biomarker targets for the evaluation of new tuberculosis vaccine candidates.
Current status: Biomarkers can help in developing new tuberculosis vaccine candidates by identifying immune
mechanisms and accurately assessing the immunogenicity and protective efficacy of a vaccine in multiple ways.
Understanding the interplay among the host immune response, vaccine candidate, and M. tuberculosis infection may
provide a platform for the identification of suitable biomarkers.
Future perspective: In this article, we review current methods for evaluating the efficacy of tuberculosis vaccine and
biomarkers used by global tuberculosis research teams and consider using these evaluation methods and biomarkers for
assessing the efficacy of the tuberculosis vaccine in Korea.
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KEYWORD
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Biomarkers, Tuberculosis, Vaccine efficacy, Host immune response, Vaccine candidate
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